Bone cancer is seen as a result of other conditions or a complication of the following conditions: kidney cancer, liver cancer, uterine cancer, esophagus cancer, endometrial cancer and Hodgkin’s disease. The cause of the bone cancer is generally unknown, as it is a result of the metastasize - the phenomenon of the cancer cells spread to the bones from the body. That is why the bone cancer is called secondary or metastatic cancer, usually spread from other organs of the body. After the kidney, liver or uterus is affected by the cancer cells, it is more likely for the cancer cells to spread and to affect the bones.

In rare cases, there may be other causes for the bone cancer and these are hereditary causes. Multiple exostoses is an inherited condition that contributes to the bone cancer. Some other inherited conditions also represent high risks of developing not only bone cancer, but also other types of cancer. These conditions may be: Li-Fraumeni syndrome, hereditary retinoblastoma and Rothmund-Thomson syndrome. Retinoblastoma is a rare type of eye cancer that may be found in the case of children and may eventually cause the bone cancer. This rare type of eye cancer is the cause of genetic information, of a faulty gene. Some people with genetic conditions may develop bone cancer, although researches try to discover the importance of such inherited genes. Moreover, sophisticated research programs hope to detect how to annihilate the development of these genetic conditions and to protect more and more people from the bone cancer development. Researches of this type may seem fabulous and being part of some science fiction novels, but the development in the genetics and in the technological field will soon permit real results in preventing the bone cancer, especially in the case of people who suffer from genetic conditions.

Another possible cause of the bone cancer is the exposure to radiation. It is the case of heavy doses, even the cases of intense radiation therapies for treating other types of cancer. The risks of developing bone cancer are higher in the case of the chosen radiation therapies for cancer treatment. Radiation therapy is not recommended in the case of treating the younger patients. This option is not the most inspired one in the case of younger patients, as it is possible to be a connection between the risk of a bone cancer among younger patients and the radiation therapy. Although the technological development has brought some changes in the appliance of treatments like the radiation therapy, this aspect is worth being taken into account before choosing it for treating a patient of a young age.

Some bone injuries may also cause bone cancer, although little research and study may confirm the truth of this statement. A bone injury may eventually show that the bone cancer has already installed there and has been there for some time. Nevertheless, when the mentioned causes are not true and the possibility of having another type of cancer, of being exposed to radiation or of having a genetic condition is not fulfilled, this may be the only reasonable explanation.

These are the most recent explanation of the bone cancer causes, although mystery still seems to surround this subject. Many physicians prefer to keep silence about the possible causes of the bone cancer, because of the fact that these causes are difficult to detect. Unlike other types of cancer, a laparoscopy or laparotomy is not possible. That is why further research and studies are needed in order to bring light to this matter. This aspect is important because if knowing the causes, some prevention information would be also available, as in the cases of other types of cancer.